Prognostic impact of the serum levels of soluble CD23 in B-cell chronic lymphocytic leukemia.

نویسندگان

  • W U Knauf
  • B Ehlers
  • B Mohr
  • E Thiel
  • I Langenmayer
  • M Hallek
  • B Emmerich
  • D Adorf
  • C Nerl
  • T Zwingers
چکیده

E, Biondi F, Lo Coco F, Grignani F, Pelicci PG: Acute promyelocytic REFERENCES leukemia: From genetics to treatment. Blood 83:10, 1994 1. Wada H, Mizutani S, Nishimura J, Usuki Y, Kohsaki M, Komai 5. Nucifora G, Rowley JD: The AML1 and ETO genes in acute M, Kaneko H, Sakamoto S, Delia D, Kanamaru A, Kakishita E: myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353, 1994 Establishment and molecular characterization of a novel leukemic 6. Offit K, Lo Coco F, Louie DC, Parsa NZ, Leung D, Portlock cell line with Philadelphia chromosome expressing p230 BCR/ABL C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyi M, Jhanwar fusion protein. Cancer Res 55:3192, 1995 S, Dalla-Favera R, Chaganti RSK: Rearrangement of the bcl-6 gene 2. Pane F, Frigeri F, Sindona M, Luciano L, Ferrara F, Cimino as a prognosic marker in diffuse large-cell lymphoma. N Engl J Med R, Meloni G, Saglio G, Salvatore F, Rotoli B: Neutrophilic-chronic 331:74, 1994 myeloid leukemia: A distinct disease with a specific molecular 7. Cervantes F, Urbano Ispizua A, Villamor N, Feliu E, Milla marker (BCR/ABL with c3a2 junction). Blood 88:2410, 1996 F, Lopez Guillermo A, Ribera JM, Granada J, Vives Corrons JL, 3. Melo JV: The diversity of BCR/ABL fusion proteins and their Monserrat E, Rozman C: Ph-positive chronic myeloid leukemia relationship to leukemia phenotype. Blood 88:2375, 1996 mimicking essential thrombocythemia and terminating into mega4. Grignani Fr, Fagioli M, Alcalay L, Longo L, Pandolfi PP, Donti karyoblastic blastic crisis. Leukemia 7:327, 1993

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منابع مشابه

Cellular expression and serum circulating levels of CD23 in B-cell chronic lymphocytic leukemia. Implications for prognosis.

BACKGROUND CD23 is a functionally relevant molecule in B-cell chronic lymphocytic leukemia (CLL) which mediates growth and differentiation signals in B-cells. An intriguing feature of CD23 is its ability to be cleaved from the cell surface and released into the serum. MATERIALS AND METHODS Serum levels of soluble CD23 (sCD23) were determined with a sandwich enzyme immunoassay at the time of d...

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Serum levels of soluble intercellular adhesion molecule 1 are increased in chronic B-lymphocytic leukemia and correlate with clinical stage and prognostic markers.

The serum levels of soluble intercellular adhesion molecule 1 (ICAM-1) were significantly elevated (P < .001) in patients with chronic B-lymphocytic leukemia (B-CLL, n = 113) compared with healthy controls (n = 31). sICAM-1 levels in B-CLL were positively correlated to the tumor mass as reflected by the modified Rai and the Binet staging systems, lymphocyte counts, and isolated spleno/hepatomeg...

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Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article

Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...

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Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia.

Prognosis of B-cell chronic lymphocytic leukemia (CLL) is based on clinical staging whose limitation is the failure to assess whether the disease will progress or remain stable in early stage (Binet A, or Rai 0, I, II) patients. We previously reported that soluble CD23 (sCD23), a protein derived from the B-cell membrane CD23 Ag, is selectively elevated in the serum of CLL patients. This prospec...

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Immunophenotypic Characterization of the Leukemic B-cells from Iranian Patients with Chronic Lymphocytic Leukemia: Association between CD38 Expression and Disease Progression

Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. Recent immunophenotypic stud-ies performed mainly in Western populations have demonstrated the prognostic value of CD38 and ZAP-70 expression in B-CLL. Objectives: To i...

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Association between rs 1800561 CD38 Gene Polymorphism and Chronic Lymphocytic Leukemia Risk

Background and purpose: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia characterized by the accumulation of seemingly mature type B lymphocytes in peripheral blood and lymphatic organs. One of the main markers used in the diagnosis and prognosis of CLL is the CD38 gene. Polymorphism is considered to be a major genetic source of phenotypic change within a species an...

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عنوان ژورنال:
  • Blood

دوره 89 11  شماره 

صفحات  -

تاریخ انتشار 1997